Paradoxical hyperfixation of HMPAO in cerebral infarction.

Paradoxical hyperfixation of hexamethylpropyleneamine oxime in cerebral infarction.

We describe four patients with cerebral infarction and 99mTc-hexamethylpropyleneamine oxime (HMPAO) hyperfixation in distributions corresponding to the infarctions seen at CT and/or MR imaging. Increased HMPAO extraction due to hyperpermeability across the blood-brain barrier and increased retention due to reduced back diffusion of the tracer probably accounted for the increased fractional fixa...

Spurious hyperfixation of hexamethylpropyleneamine oxime in acute embolic stroke.

A 71-year-old man with atrial fibrillation suddenly had an embolism in the right middle cerebral artery. Single-photon emission CT was performed 4 hours after the onset of stroke and revealed markedly elevated 99mTc-hexamethylpropyleneamine oxime (HMPAO) uptake in the right frontotemporoparietal region. This area of HMPAO hyperfixation corresponded to the area of infarction, as determined by CT...

Hyperfixation of HMPAO in subacute ischemic stroke leading to spuriously high estimates of cerebral blood flow by SPECT.

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Spuriously High Estimates of Cerebral Blood Flow by SPECT

W e want to report an error in interpreting d,l-hexamethylpropylene amine oxime (HMPAO) tomograms as cerebral blood flow (CBF) in subacute ischemic stroke cases. By simultaneously studying CBF by `33Xe dynamic single-photon emission computed tomography (SPECT), an obvious discrepancy was noted in that the HMPAO tomograms grossly exaggerated the reflow hyperemia following spontaneous reperfusion...

A spurious description of hyperfixation of HMPAO.